Modified-Release Prednisone May Ease Rheumatoid Arthritis
THURSDAY, Jan. 17 (HealthDay News) A modified-release form of the steroid prednisone is better than the standard, immediate-release version at reducing morning joint stiffness in people with rheumatoid arthritis, a new study finds.
German researchers at Charite University Medicine Berlin studied 288 people with active rheumatoid arthritis. Half took standard prednisone (a glucocorticoid) when they woke in the morning and half took modified-release prednisone at bedtime. The modified-release tablets dispense prednisone four hours after ingestion.
After 12 weeks of treatment, patients taking the modified-release version experienced an average of 44 minutes less morning stiffness per day than at the start of the study. That was 29.2 minutes less than those who took the standard version, the team noted.
Their report is published in the Jan. 19 issue of The Lancet.Read entire article...